Journal article
Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection
M Doerflinger, Y Deng, P Whitney, R Salvamoser, S Engel, AJ Kueh, L Tai, A Bachem, E Gressier, ND Geoghegan, S Wilcox, KL Rogers, AL Garnham, MA Dengler, SM Bader, G Ebert, JS Pearson, D De Nardo, N Wang, C Yang Show all
Immunity | CELL PRESS | Published : 2020
Abstract
The clearance of intracellular pathogens requires the killing of infected cells, but it remains unclear why host cells have so many different means of inducing programmed cell death. Doerflinger et al. demonstrate that interconnectivity between pyroptosis and apoptosis involving flexible deployment of caspases ensures control of Salmonella infection in mice.
Grants
Awarded by Cass Foundation
Funding Acknowledgements
We thank M. Patsis and G. Siciliano for expert animal care, B. Helbert and K. Mackwell for genotyping, S. Monard and his team for help with flow cytometry, V. Dixit and N. Kayagaki for insightful discussions, and all the members of the Herold, Strasser, and Bedoui laboratories. We thank Gordon Dougan (University of Cambridge) for the SL1344 GFP-expressing Salmonella strain. This work was supported by grants and fellowships from the Australian National Health and Medical Research Council (NHMRC) (project grants 1186575 and 1145728 to M.J.H., 1143105 to M.J.H. and A.S., 1159658 to M.J.H. and S.B., and 1016701 to A.S.; and fellowships 1020363 to A.S. and 1156095 to M.J.H.), the Leukemia and Lymphoma Society of America (LLS SCOR 700113 to A.S. and M.J.H.), the Cancer Council of Victoria (project grants 1147328 to M.J.H. and 1052309 to A.S., and a venture grant to M.J.H. and A.S.), the Australian Phenomics Network (to M.J.H. and A.J.K.), the Cass Foundation (to M.D.), the Wellcome Trust (investigator award 108045/Z/15/Z to C.E.B.), and the German Research Council (GRK2168 to S.E. and S.B.), as well as by operational infrastructure grants through the AustrYalian Government Independent Research Institute Infrastructure Support Scheme (361646 and 9000220) and the Victorian State Government Operational Infrastructure Support Program. The graphical abstract was created with the help of BioRender.com.